When Jesus is on the cross and quotes Psalm 22:1, “My God, my God, why have you forsaken me?” He is also describing his present, insufferable separation from his heavenly Father. From eternity past, Jesus had never known what it was like to be alienated from God’s presence. At some level, the Father turns His back on Jesus as He becomes the embodiment of sin (2 Corinthians 5:21). Jesus is forsaken by God, that is, He is abandoned, left without God’s resources or intervention, to suffer and die alone.
God’s abandonment may be harsh, but it is only temporary. After all, behind the cross is an empty tomb.
So Jesus knows intimately (magnified!) what being alone and suffering is like. He knows the worst that we can experience in this life.